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Camps quinoline synthesis
The Camps quinoline synthesis (also known as the Camps cyclization) is a chemical reaction whereby an o-acylaminoacetophenone is transformed into two different hydroxyquinolines (products A and B) using hydroxide ion.〔Camps, R.; ''Ber.'' 1899, ''22'', 3228.〕〔Camps, R.; ''Arch. Pharm.'' 1899, ''237'', 659.〕〔Camps, R.; ''Arch. Pharm.'' 1901, ''239'', 591.〕〔Manske, R. H. F.; ''Chem. Rev.'' 1942, ''30'', 127. (Review)〕
The relative proportions of the hydroxyquinolines (A and B) produced are dependent upon the
reaction conditions and structure of the starting material. Although the reaction product is commonly depicted as a quinoline (the enol form), it is believed that the keto form predominates in both the solid state and in solution, making the compound a quinolone.〔
An example of the Camps reaction is given below:〔''Sequential Cu-Catalyzed Amidation-Base-Mediated Camps Cyclization: A Two-Step Synthesis of 2-Aryl-4-quinolones from o-Halophenones'' Jones, C. P.; Anderson, K. W.; Buchwald, S. L. J. Org. Chem.; (Article); 2007; 72(21); 7968-7973. 〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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